Private: IEC Progress to Date

Since our founding in 2014, the IEC has already built a strong foundation for future success. Some of the highlights include:

SEMINARS AND SYMPOSIA

  • IEC’s program on Microbiome will be held on February 15 at the 2018 American Academy of Dermatology Annual Meeting.  Co-Chairs Amy Paller and Thomas Luger will be joined by speakers Richard Gallo, Alan Irvine, Heidi Kong, Shruti Naik, Tiffany Scharschmidt, and Patrick Seed.
  • The IEC’s first meeting in Asia was held on December 15, 2017 at the Annual Meeting of the Japanese Society for Investigative Dermatology (JSID) in Kochi, Japan.  Amy Paller and Emma Guttman joined co-chairs Masa Amagai and Kenji Kabashima for this program
  • In September 2017, the IEC presented a program at the European Society for Dermatological Research meeting in Salzburg, Austria focusing on the Role of Environmental Factors in AD.  Co-chairs Sara Brown and Thomas Werfel were joined by speakers Claudia Traidl-Hoffmann and Jean Krutmann.  The goals of this program were to increase the understanding of gene-environment interactions in the pathogenesis of atopic eczema and to increase the understanding of the relationship between air-pollution, allergen exposure and the microbiome to disease activity of atopic eczema.
  • At the 2017 EADV meeting in Geneva, Switzerland, the IEC presented a symposium focusing on Pruritus, Neuroinflammation and Therapeutic Strategies. The goals of the program were to increase the understanding of pathomechanisms of itch in systemic and skin disease and the therapeutic approaches to itch based on underlying pathomechanisms.  Our co-chairs for this program were Thomas Luger and Nicholas Reynolds, and featured speakers include Martin Steinhoff, Ethan Lerner, Sonja Staender, Kenji Kabashima, and Diamant Thaci.
  • The IEC’s program at the 2017 SID in Portland, Oregon included our featured speaker, Masa Amagai, five interesting abstract presentations, and the Roadmap for AD at the 2017 SID
  • A joint seminar with International Psoriasis Council at 2017 AAD in Orlando, Florida entitled Evolving Perspectives on Psoriasis and Atopic Dermatitis: Are They Two Diseases or One Spectrum? was developed after the great success of our EADV seminar with IPC in September 2016.  This seminar featured new speakers, and new and expanded topic areas (Genetics, Comorbidities.)  Both sessions were video-taped and available via on-demand webcast. In addition, a manuscript is currently under development for the EADV program.
  • The IEC held an educational session in November 2016 the morning before the Inflammatory Skin Disease Summit (ISDS) in New York, and featured discussions on topical and systemic therapies included a powerful spotlight on adult and pediatric patients and parents (featuring actual patients and parents), and roundtable discussions with patients, caregivers and physicians, and lectures on novel AD treatments.
  • In May 2016, IEC presented a program at the SID featuring Kenji Kabashima as well as numerous abstract presentations and a Roadmap for the 2016 SID.
  • IEC’s inaugural seminar held at the 2016 AAD annual meeting entitled Atopic Dermatitis and Personalized Medicine: Phenotyping for Classification and Predicting Co-Morbidities.  Speakers were Amy Paller, Jonathan Silverberg, Georg Stingl, Tali Czarnowicki, Emma Guttman, and Thomas Bieber.

COUNCILOR AND ASSOCIATE SESSIONS

  • Numerous Councilor’s meetings have been held at major annual meetings leading to manuscripts. Various articles have been already been published including:
    • Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder. Brunner PM, Silverberg JI, Guttman-Yassky E, Paller AS, Kabashima K, Amagai M, Luger TA, Deleuran M, Werfel T, Eyerich K, Stingl G; Councilors of the International Eczema Council. J Invest Dermatol. 2017 Jan;137(1):18-25. doi: 10.1016/j.jid.2016.08.022. Epub 2016 Oct 20.
    • When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council. Simpson EL, Bruin-Weller M, Flohr C, Ardern-Jones MR, Barbarot S, Deleuran M, Bieber T, Vestergaard C, Brown SJ, Cork MJ, Drucker AM, Eichenfield LF, Foelster-Holst R, Guttman-Yassky E, Nosbaum A, Reynolds NJ, Silverberg JI, Schmitt J, Seyger MMB, Spuls PI, Stalder JF, Su JC, Takaoka R, Traidl-Hoffmann C, Thyssen JP, van der Schaft J, Wollenberg A, Irvine AD, Paller AS. J Am Acad Dermatol. 2017 Aug 10. pii: S0190-9622(17)31944-8. doi: 10.1016/j.jaad.2017.06.042. [Epub ahead of print]
    • What’s in a name? Atopic dermatitis or atopic eczema, but not eczema alone. Silverberg JI, Thyssen JP, Paller AS, Drucker AM, Wollenberg A, Lee KH, Kabashima K, Todd G, Schmid-Grendelmeier P, Bieber T. Allergy. 2017 Jun 12. doi: 10.1111/all.13225. [Epub ahead of print]
    • Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. Drucker AM, Eyerich K, de Bruin-Weller MS, Thyssen JP, Spuls PI, Irvine AD, Girolomoni G, Dhar S, Flohr C, Murrell DF, Paller AS, Guttman-Yassky E. Br J Dermatol. 2017 Sep 2. doi: 10.1111/bjd.15928. [Epub ahead of print]
  •  IEC Councilor sessions have either been held or are planned to study and develop manuscripts on various topics including:
    •  High placebo rates in AD clinical trials
    •  Value or lack of value of anti-staphylococcal medications
    •  Human models of eczema
    •  Unmet Needs in AD
    •  Patient Education
  • The IEC Councilors and Associates met in a special session at the World Congress of Pediatric Dermatology meeting in Chicago, IL in July 2017 to discuss developing documentation and templates of best practices and outcomes in AD. Subcommittees have been developed to:
    • Develop core datasets with levels (routine clinic practice; study; patient comprehensive registry)
      • Within this group, sub-subgroups on collection of PROs by computer/paper and another on other data collection (historical, examination)
    •  Logistics of the database technology/ de-identification, interface to paste into EMR, etc.

PROJECTS

  • We are grateful to Dr. Fabio Nunes and Lilly for spearheading the project to develop the validated Investigator’s Global Assessment for Atopic Dermatitis (vIGA-AD™ ) scale. We also appreciate the willingness of other pharma companies to join in (e.g., Galderma, Abbvie.) More than a dozen IEC members worked on developing a new IGA, calibrating it, validating it, and making a teaching program so that it can be widely used for clinical trials. The adult training video is complete and a pediatric one is in the works. There will be further validation after training.   See the IEC website for further information regarding the vIGA-AD™ scale.
  • The IEC is excited to announce the launch of educational modules for AD clinical investigators. These modules were developed by Eric Simpson and  GlaxoSmithKline LLC, and donated to the IEC. The topic areas covered are: 1) Calculating % Body Surface Area (BSA) and Eczema Area Severity Index (EASI) Score 2) Target Lesion Severity Score (TLSS) for the Assessment of AD. The modules can be accessed at www.trifectaclinical.com. We are grateful to the following for making available to the clinical community: Steve Frey, Tomoko Maeda-Chubachi, Eric Simpson, Fabio P. Nunes, Eli Lilly and Company, and GlaxoSmithKline LLC.
  • Donated $10K to the development of an AD Guidance Document (and our Councilors are involved in its preparation as Committee Chairs) which was recently presented to the FDA. The document is available for review and comments at: https://www.regulations.gov/document?D=FDA-2017-D-3800-0001 
  • Jonathan Silverberg and Thomas Bieber are co-chairs of the IEC Payer Education Workgroup which is comprised of IEC Councilors and Associates as well as representatives of industry working together to identify and meet the educational needs of payers regarding Atopic Dermatitis. An exploratory survey is underway with this group to understand the various endpoints and related issues for regulators, payers/HTAs, and clinical practice.
  • IEC leaders will convene at the 2018 IID to conduct a strategic planning session to outline goals and priorities for the next three years, including education beyond dermatologists (e.g., residents).
  • Top 10 Publications on Atopic Dermatitis for 2016 and 2015 chosen by Councilors and posted on website. The Top 10 for 2017 will be underway shortly.
  • Inaugural issue of the IEC e-newsletter
  • International Board of Directors and bylaws established.
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