Microbiome

At SID 2022 | May 18, 2022, 10:00 - 1:15 pm PDT 

Oregon Convention Center | B117-B119 | Portland, OR, USA 

Learn about microbiome and atopic dermatitis during a complimentary educational symposium during the Society for Investigative Dermatology (SID) 2022 annual meeting in Portland, OR.  Learn more about the SID 2022 annual meeting. 

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PROGRAM CHAIRS

Tiffany C. Scharschmidt, MD
Associate Professor | UCSF Department of Dermatology

Heidi H. Kong, MD, MHSc
Senior Investigator, Dermatology Branch/NIAMS
Adjunct Investigator, Laboratory of Integrative Cancer Immunology/CCR/NCI

PROGRAM GOALS

• Review the role of the human microbiome in atopic eczema.
• Discuss the interaction of the microbiome with the skin immune system.
• Examine potential future applications of atopic eczema microbiome research.

AGENDA 

10:00 – 10:10 am Welcome & Program Overview | Co-Chairs, Tiffany Scharschmidt, MD and Heidi Kong, MD, MHSc 

10:10 – 10:40 am  Skin Microbiome Signatures in Atopic Dermatitis| John Common, PhD | A*STAR 

Investigating microbial communities present on the skin of atopic dermatitis (AD) patients has led to a deeper understanding of the shifts in community diversity and functional gene pathways. These dynamic shifts across the flare cycle and according to the underlying endotypes of AD provide potential intervention points for topical therapies to reduce infections. We have also recently identified the shared microbiome signatures that exist between children with AD and their caregivers. This supports the inclusion of family members in microbial-based strategies for treating recurrent paediatric AD.

10:40 – 11:10 am  On-Person Adaptive Evolution of Staphylococcus aureus During Treatment for Atopic Dermatitis | Tami Lieberman, PhD | MIT

Genetic variation among S. aureus strains is thought to contribute to heterogeneity in the severity of atopic dermatitis, but the degree of variation created by de novo mutation during colonization is not well understood. Here, I will present our results from longitudinal tracking S. aureus on-person evolution on 25 children treated for AD over 9 months.

11:10 – 11:25 am Heterogeneity in Cutaneous Infection Prevalence and Frequency by Timing of Atopic Dermatitis Onset | Saloni Shah, BA | Thomas Jefferson University

11:25 – 11:40 am  Staphylococcus aureus Proteases Trigger Skin Inflammation via Eosinophil-Derived IL-17 Responses | Sabrina J. Nolan, PhD | Johns Hopkins University School of Medicinie

11:40 – 11:55 am  Break 

11:55 – 12:25 pm Infantile Eczema and Staphylococcus aureus Agr Mutations | Yumi Matsuoka-Nakamura, MD, PhD | Osaka University

Agr quorum-sensing associated toxin productions from Staphylococcus aureus play some important roles in atopic dermatitis. We analyzed longitudinal changes of infant skin microbiome and S. aureus skin colonization in a skin care intervention study. Compared to previous Japanese infant cohort studies, the skin care intervention reduced the risk of infantile eczema/atopic dermatitis and increased the agr-mutation rate in skin-colonized S. aureus while this intervention did not reduce the risk of food-allergen sensitization. Food-allergen sensitized infants at one year-old have less microbiome diversity of their skin at one month of age independent of infantile eczema. 

12:25 – 12:55 pm  Host-Microbiome Metabolic Interactions in Atopic Dermatitis | Helen Alexander, MD | King’s College London

This talk will focus on host-microbiome interactions in AD, to include microbial metabolites as potential mediators of host-microbiome interactions. The AD gut microbiome and potential metabolic cross-talk between gut and skin will also be discussed. 

12:55 – 1:10 pm  Botanical inhibitors of Staphylococcal Virulence: A New Path Toward Mitigating Atopic Dermatitis Severity? | Cassandra Quave, PhD | Emory University School of Medicine

1:10 – 1:15 pm Closing Comments & Adjournment | Co-Chairs, Tiffany Scharschmidt, MD and Heidi Kong, MD, MHSc

This educational symposium presented by the IEC is offered at no cost to attendees.

HEALTH AND SAFETY TRAVEL RESOURCES

IEC and SID will comply with state and local mandates at the time of the in-person meeting.  Learn more here.  

COVID-19 VACCINATION STATUS

The SID is requiring proof of full COVID-19 vaccination (plus booster) for admittance to ALL SID in-person meetings and events.  Click this link to see a list of approved vaccines.

For those traveling internationally, there may be additional requirements in place. Please check with your airline and current U.S. entry guidelines.