Top Ten Articles 2019

1. Guttman-Yassky, E., et al. Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial.” J Allergy Clin Immunol. 2019;145(3): 877-884.
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2. Guttman-Yatsky, E. et al. Use of Tape Strips to Detect Immune and Barrier Abnormalities in the Skin of Children With Early-Onset Atopic Dermatitis.  JAMA Dermatol. 2019;155(12): 1358-137.
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3. Zhou, L., et al. Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2019;144(1): 144-156.
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4. Simpson, E., et al. Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial. JAMA Dermatol. 2019;156(1): 44-56.
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5. Pavel, AB et al. Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis. J Allergy Clinical Immunol. 2019;144(4): 1011-1024.
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6. Brunner, P., et al. The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease.” J Am Acad Dermatol. 2019;81(2): 510-519.
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7. Guttman-Yattsky, E., et al. GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis.  J Allergy Clin Immunol. 2019;144(2): 482-493.
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8. Czarnowicki, T., et al. Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood.” J Allergy Clin Immunol. 2019;145(1): 215-228.
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9. Nakagawa, H., et al. Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis.” J Allergy Clin Immunol. 2019;144(6): 1575-1583.
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10. Fyhrquist, N., et al. Microbe-host Interplay in Atopic Dermatitis and Psoriasis. Nat Commun. 2019;10(1): 4703.
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Other Important Articles in AD: Chosen by the International Eczema Council.

1. Tsoi, L., et al. Progression of Acute-To-Chronic Atopic Dermatitis Is Associated With Quantitative Rather Than Qualitative Changes in Cytokine Responses.” J Allergy Clin Immunol. 2019;S0091-6749(19)32610-7.
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2. Abuabara, K., et al. Clinical Onset of Atopic Eczema: Results From 2 Nationally Representative British Birth Cohorts Followed Through Midlife. J Allergy Clin Immunol. 2019;144(3): 710-719.
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3. Matthias, J., et al. Sodium Chloride Is an Ionic Checkpoint for Human T H 2 Cells and Shapes the Atopic Skin Microenvironment”. Sci Transl Med. 2019;11(480):eaau0683.
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4. Pavel, A., et al. The Proteomic Skin Profile of Moderate-To-Severe Atopic Dermatitis Patients Shows an Inflammatory Signature. J Amer Acad Dermatol. 2019;82(3): 690-699.
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5. Guo, C., et al. Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation. J Invest Dermatol. 2019;S0022-202X(19)33568-7.
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6. Worm, M. et al. Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis: A Randomized Clinical Trial. JAMA Dermatol. (2019);156(2): 131-143.
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7. Kim, B., et al. Treatment of Atopic Dermatitis With Ruxolitinib Cream (JAK1/JAK2 Inhibitor) or Triamcinolone Cream. J Allergy Clin Dermatol. 2019;145(2): 572-582. JAMA Dermatol. 2019;156(2): 131-143.
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8. Mucha, S. et al. Protein-coding Variants Contribute to the Risk of Atopic Dermatitis and Skin-Specific Gene Expression. J Allergy Clin Immunol. 2019;145(4): 1208-1218.
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9. Paller, A., et al. Clinically Meaningful Responses to Dupilumab in Adolescents With Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses From a Randomized Clinical Trial. Am J Clin Dermatol. 2019;21(1): 119-131.
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10. Ryffel, B., et al. ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.” J Invest Dermatol. 2019;139(10):2077-2079.
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11. Ravn, N.H., et al. How Does Parental History of Atopic Dermatitis Predict the Risk of Atopic Dermatitis in a Child? A Systematic Review and Meta-Analysis. J Allergy Clin Immunol. 2019;145(4): 1182-1193.
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